2026年4月1日

    BIOGRAFT®

    Collagen Membrane Forming Hydrogel, derived from Placenta

    BIOGRAFT* is a brand-new placental biomaterial developed by the placental biomaterial venture - RE Biotech, produced by Japan Bio Products CO., Ltd.

    *BIOGRAFT is a registered trademark of Japan Bio Products CO., Ltd.

    BIOGRAFT®* is made by using placenta-derived collagen. This collagen is,
    ・extracted without heat treatment.
    ・subjected to atelocollagen** treatment.
    After that, through own manufacturing method (Patent Law no.759377), BIOGRAFT has fluidity at low temperature and formulated to form an atelocollagen film at near body temperature (37℃).

    *BIOGRAFT is a registered trademark of Japan Bio Products CO., Ltd.
    ** Atelocollagen treatment removes telopeptide from both ends in N/C terminal, preventing its antigenicity for recipients.

    Dermal membrane protection, without any stress

    The placental-collagen membrane has unique characteristics.

    ＜Strength for protecting, Softness for fitting in the skin, Easily removed with mere water＞

    BIOGRAFT🄬 merged three contradicting characteristics.

    Strength: adequate stiffness and adhesion to maintain its guard for several hours
    Softness: While protecting the skin, natural collagen fits in a moving body
    Easy to remove: It can be removed with just water, without burdening the skin.

    ＜Condition＞ The experiment was conducted in 2025. N=1 (male, 40s)

    ＜test device＞ Collagen Membrane Forming Hydrogel Agent（1.8% collagen, BIOGRAFT®）

    ＜control＞ Film-forming agent with high adhesiveness (chemical synthetic product, general distribution product）

    ＜Method＞ Test and control devices were respectively applied to the left and the right arms, confirming that the membrane or film was built. The subject had been wearing long-sheered clothes for 8 hours. Both sides of the part where the membrane and film were formed were marked with oily ink and subsequently washed. If the washing treatment couldn’t remove it, a physical peel-off treatment was additionally applied.

    ＜Results＞ On the side of the test device, it could maintain a membrane for 8 hours, under conditions of clothing and life-activity, and it was observed that the membrane was removed with just washing treatment.

    ＜Protecting from outside stimulus, but not hindering the inside dermal physiological function＞

    The atelocollagen membrane formed by BIOGRAFT🄬 absorbs the excess sebum secreted from the skin.

    ＜Condition＞ The experiment was conducted in 2025. N=1(male,40s）.

    ＜Test device＞ Collagen Membrane Forming Hydrogel Agent（1.8% collagen, BIOGRAFT®）

    ＜control＞ Film-forming agent with high adhesiveness (chemical synthetic product, general distribution product）

    ＜Samples＞ The following samples were collected and analyzed by the same method.
    ・Sebum sample: it was obtained from a part of the subject’s right cheek.
    ・Before application: Both the test device and the control were used directly as samples.
    ・After application: Both test device and control were applied to the left and right cheeks, respectively; after 8 hours, the membrane and film were gently peeled off as samples.

    ＜Analysis＞ The lipid sample was extracted by the Bligh & Dyer method, separated using Ultra High Performance Liquid Chromatography, and detected with Quadrupole Time-of-Flight Mass Spectrometry.

    ＜Results＞ A molecular weight peak similar to that of the sebum sample was detected in the test device after 8 hours of application. The results showed that the membrane absorbed the sebum.

    ＜Optimal amount of moisture and sebum, making the environment comfortably functioning for the skin＞

    Continuous daily use of BIOGRAFT🄬 improves the skin's surface moisture level and barrier function, as measured by TEWL.

    ＜Condition＞ Conducted from November to December in 2024, N=4 (male,30-40 y.o.)

    ＜Test device＞ Collagen Membrane Forming Hydrogel Agent（1.8%collagen, BIOGRAFT®）

    ＜Method＞ The period lasted three (3) weeks in total. The subjects applied approximately 0.8ml to their entire face before bedtime. During the test, the use of basic cosmetics other than the test device was prohibited.

    ＜Results＞ Measurements with the Corneometer (for moisture level) and the Tewameter (for TEWL) were performed before and after the test, showing that all subjects achieved values above 50% and below 20 g/h/m2, respectively. All measurements were conducted after they washed their faces.

    ＜Collagen Membrane Forming Hydrogel Agent＞

    BIOGRAFT can balloon the application of atelocollagen thus far in the field of medical science. The intellectual property information related BIOGRAFT🄬 is as follows. Collagen Membrane Forming Hydrogel Agent (No. 759377).

    Trade mark: BIOGRAFT®

    ＜Feel free to contact us !＞

    You can inquire about BIOGRAFT🄬 through this URL.
    https://rebiotech.co.jp/contact